Crystal structure of human nicotinic acid phosphoribosyltransferase
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چکیده
منابع مشابه
Crystal structure of human nicotinic acid phosphoribosyltransferase
Nicotinic acid phosphoribosyltransferase (EC 2.4.2.11) (NaPRTase) is the rate-limiting enzyme in the three-step Preiss-Handler pathway for the biosynthesis of NAD. The enzyme catalyzes the conversion of nicotinic acid (Na) and 5-phosphoribosyl-1-pyrophosphate (PRPP) to nicotinic acid mononucleotide (NaMN) and pyrophosphate (PPi). Several studies have underlined the importance of NaPRTase for NA...
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Nicotinic acid phosphoribosyl transferase (NAPRTase) and nicotinamide deamidase activities from Salmonella typhimurium were examined regarding their regulation by either feedback inhibition or repression mechanisms. The results indicate that neither enzyme is subject to feedback inhbition. Nicotinamide deamidase does not appear to be under repression control. NAPRTase, however, is repressed whe...
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ژورنال
عنوان ژورنال: FEBS Open Bio
سال: 2015
ISSN: 2211-5463
DOI: 10.1016/j.fob.2015.05.002